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The Neurology of AIDS

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The Neurology of AIDS

Book Detail

Author/Editor(s): Howard E. Gendelman, Igor Grant, Ian Paul Everall, Howard S. Fox, Harris A. Gelbard, Stuart A. Lipton, Susan Swindells
Publication Date: November 29, 2011
ISBN-10: 019539934X
ISBN-13: 978-0195399349
Language: English
Edition: 3
Publisher: Oxford University Press
Size: 24.4 MB
Format: pdf

Book Description

Neurological complications of progressive HIV-1 infection remain a common cause of morbidity even during widespread use of antiretroviral therapy (ART). Long-term resistance to ART, drug compliance, untoward drug side effects, a myriad of opportunistic infection, depression and other psychiatric disease manifestations, concomitant drug abuse, neuropathies, and an inability to clear viral reservoirs, explain, in large measure, disease progression and immune deterioration. These are associated with a number of psychiatric, muscle, nerve, infectious, as well as cognitive, behavioral, and motor disturbances seen in infected people.

Fully updated from the previous two editions and replete with color images, The Neurology of AIDS, Third Edition covers each of these neurological complications and more with a focus on molecular and viral disease processes, cellular factors influencing viral replication therapeutic challenges, and the changing epidemiological patterns of disease. From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field.

About the Author

Howard E. Gendelman, MD, Professor and Chair, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha, NE.

Igor Grant, MD, Distinguished Professor of Psychiatry, Director, HIV Neurobehavioral Research Program, University of California-San Diego, La Jolla, CA.

Ian Paul Everall, MD, PhD, Professor of Psychiatry and Head of Department, University of Melbourne, Victoria, Australia.

Howard S. Fox, MD, PhD, Professor, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE.

Harris A. Gelbard, MD, PhD, Director of The Center for Neural Development and Disease, Professor of Neurology, Pediatrics, Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY.

Stuart A. Lipton, MD, PhD, Professor and Scientific Director, Sanford-Burnham Medical Research Institute; Adjunct Professor of Neurosciences, University of California-San Diego; Adjunct Professor, The Salk Institute for Biological Studies and The Scripps Research Institute, La Jolla, CA.

Susan Swindells, MBBS, Professor of Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.


This large book...offers a wealth of up-to-date information on the myriad neurologic disorders associated with HIV infection.... The book is at its best as a source of in-depth, extensive, and scholarly analysis of the neurobiology of HIV, especially regarding the cognitive impairments that prevail despite highly active antiretroviral therapy.

--The New England Journal of Medicine

The goal of the authors is to contribute to the control of HIV disease until it is fully medically manageable, and to the eventual worldwide control of HIV's epidemic spread. These are worthy objectives and the book definitely meets them.


...the organization and the quality of the book's content suggest that it will appeal to a large audience including students, clinicians, researchers and other health care providers, who will find it an important resource and reference for information about the neurological aspects of HIV infection.

--Neuromuscular Disorders

This impressive text manages to encompass a vast array of topics and perspectives related to the neuropsychiatric manifestations of HIV infection...The Neurology of AIDS is essential for institutions that care for those living with HIV infection and is an approachable text for students, residents, researchers, and clinicians.

--Journal of the American Medical Association

I have referred to (and in some cases read cover to cover) many textbooks, but not before the 3rd Edition of The Neurology of AIDS would I have thought of the word 'breathtaking.' Howard Gendelman and his contributors have produced a masterpiece. HIV/AIDS is a remarkable disease, and in some sense demands a remarkable book such as this. The book is comprehensive, covering every conceivable topic, ranging from molecular biology to epidemiology to all clinical aspects (including the words of patients reflecting their suffering). It is authoritative (all scientific and clinical contributors are world renowned). And it is well-organized and well-written. A must have book for anyone working in the field of HIV/AIDS.

--Phillip K. Petersen, MD, Professor of Medicine, Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, MN

This is an impressive and in-depth text that provides a timely update on a vast array of topics related to HIV-1 infection of the central nervous system. The book encompasses HIV-1 biology and immunology, the role of the blood-brain barrier in HIV entry into the central nervous system, the cellular and viral neurotoxicity of abused drugs in relation to HIV infection, animal models for studying HIV infection and pathogenesis, clinical and pathologic manifestations of HIV disease, co-morbid conditions in HIV infection, diagnostic and biomarker approaches applicable to HIV infection, antiretroviral and adjunctive therapies, and the psychiatry and psychobiology linked to HIV diseaseEL.In sum, The Neurology of AIDS, 3rd ed. is a treasure trove of the latest information on the neurobiology of HIV/AIDS.

--Guy A. Cabral, PhD, Department of Microbiology & Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA

This is exactly what the editors had in mind: a reference and resource on nervous system disorders associated with HIV. It is doubtful that any one reader will find all sections equally useful or interesting, but the book was written with a very diverse audience in mind. It does a beautiful job of fulfilling the editors' goals.

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